Research paper on aids hiv

AIDS, which stands for Acquired Immunodeficiency Syndrome, is a human viral disease that corrupts the immune system, shutting down the body's ability to defend itself from infection and disease.

causes of hiv/aids

In this layout, the papers that cite the same papers tend to stick together making easier the visualization of the research fronts. For example, recognition of the increased incidence of heart disease in the HIV population that is associated with chronic inflammation has stimulated interdisciplinary advances in understanding and treating coronary heart disease apart from HIV infection [ 22 ].

KH Coder delivered several outputs. The study of the emerging research fronts offers the possibility of analyzing the relationship between the paradigms and the organizational process of the scientific communities [ 141617 ].

The selectivity of this defect and its resulting catastrophic effect on host defense mechanisms, as manifested by the wide range of opportunistic infections and neoplasms, underscore the critical role this cell type plays in the overall regulation of the human immune system.

Research paper on aids hiv

Role of Immune Activation in Disease Pathogenesis Studying the pathogenesis of HIV disease has clearly demonstrated that aberrant immune activation stimulated by virus replication is the driving force of HIV replication [ 19 ]. The design of immunogens based on the precise conformation of epitopes in the viral envelope as they bind to neutralizing antibodies has been perfected within the arena of HIV vaccine immunogen design. Objective Through a combination of text mining and network analysis, we sought to understand the emergence and evolution of the research fronts the footprints of the research communities that produced the paradigmatic explanation of this disease. The number of papers of each research front was plotted over the years in order to track the dynamics of the research fronts. Structure-Based Vaccine Design Although a safe and effective HIV vaccine has not yet been developed, the discipline of structure-based vaccine design using protein X-ray crystallography and cryoelectron microscopy has matured greatly in the context of HIV vaccine research. Most infections are harmless in healthy people, but people with AIDS can dies from those same infections. In this regard, the flagrant immune activation associated with uncontrolled virus replication, as well as the subtle immune activation associated with control of virus replication, are important pathogenic triggers of the increased cardiovascular and other organ system diseases associated with HIV infection. In this respect, HIV infection functions as a natural experiment that elucidates the complexity of the human immune system. This algorithm considers the nodes as charged particles that exhibit repulsive forces and the vertices as springs. The reality of utilizing these technologies in resource-poor areas accelerated the advancement of new simplified, automated, affordable, and portable point-of-care devices with broader implications for clinical medicine [ 18 ]. KH Coder delivered several outputs.

These 5, highly cited papers formed a network of 86, inter-citations Fig 1. The content of the identified research fronts -the abstract of their papers- was analyzed with KH Coder [ 34 ], a software for quantitative content analysis Text mining.

Both authors: No reported conflicts of interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. In this respect, HIV infection functions as a natural experiment that elucidates the complexity of the human immune system.

A citation network of those papers was constructed. The sub-modules that form front 1 were identified. However, we considered that the most informative output was the list of the most distinctive words which provided key information about what was the main focus of the papers of each front.

Research paper example

KH Coder delivered several outputs. These 5, highly cited papers formed a network of 86, inter-citations Fig 1. Previous studies using the research fronts analysis approach were mainly focused in topics from engineering [ 24 , 25 ], biotechnologies [ 18 ] and scientometrics [ 26 ]. This has provided substantial insights into the pathogenesis of an array of other diseases characterized by aberrancies of immune regulation. This algorithm considers the nodes as charged particles that exhibit repulsive forces and the vertices as springs. Structure-Based Vaccine Design Although a safe and effective HIV vaccine has not yet been developed, the discipline of structure-based vaccine design using protein X-ray crystallography and cryoelectron microscopy has matured greatly in the context of HIV vaccine research. In essence, the somewhat paradoxical situation exists whereby the very immune activation triggered by the virus in an attempt to control virus replication creates the microenvironment where the virus efficiently replicates. The biggest and oldest front is related to the clinical knowledge on the disease in the patient. However, while such a historical perspective is informative, they present two disadvantages: the first is that the selection of the most relevant discoveries is arbitrary, i. The study of the emerging research fronts offers the possibility of analyzing the relationship between the paradigms and the organizational process of the scientific communities [ 14 , 16 , 17 ]. That is, citation patterns of scientists exhibit homophily [ 14 , 19 ], which is caused by the scientists trend to cite those papers that focus in similar topics with a similar approach -and very often they cite those papers that strengthen the papers argumentation [ 14 , 19 , 20 ]. In this respect, HIV infection functions as a natural experiment that elucidates the complexity of the human immune system. Around the world, AIDS has been a top killer for many people throughout the 20th century and is spread numerous ways. Potential conflicts of interest. The most common way to contact and spread HIV is by having sex with an infected person.
Rated 8/10 based on 84 review
Download
AIDS Research Paper essays